Metallothionein in Biology and MedicineThis book brings together work from leading researchers to present the most recent advances in research on metallothionein. This protein interests toxicologists because it is thought that metallothionein protects against metal toxicity and possibly against oxidative stress. It is of interest to pharmacologists because modification of metallothionein levels might have a role in cancer chemotherapy. Nutritionists have an interest in this protein because it appears to be a major storage protein for zinc. Biochemists and molecular biologists will be interested in the mechanisms of regulation of this protein because it is extremely inducible. |
ما يقوله الناس - كتابة مراجعة
لم نعثر على أي مراجعات في الأماكن المعتادة.
المحتوى
| 1 | |
| 13 | |
| 25 | |
| 49 | |
| 63 | |
| 75 | |
| 87 | |
MOLECULAR BIOLOGY OF THE CHICKEN | 103 |
EFFECTS OF EPIDERMAL GROWTH FACTOR | 237 |
CHANGES IN LOCALIZATION OF | 249 |
STUDIES ON INDUCTION OF ZINC | 265 |
INDUCTION OF METALLOTHIONEIN BY | 271 |
HORMONAL INDUCTION OF METALLOTHIONEIN | 283 |
THE METALLOTHIONEIN GENE FAMILY | 295 |
EFFECT OF PREINDUCTION OF | 305 |
PROXIMAL TUBULE CELL INJURY | 311 |
SPECIES DIFFERENCES IN METALLOTHIONEIN | 121 |
METALLOTHIONEIN AND SULFUR METABOLISM | 133 |
CADMIUMBINDING PROTEINS IN TARGET | 145 |
ABSORPTION OF CADMIUMMETALLOTHIONEIN | 165 |
ROLE OF METALLOTHIONEIN IN EPITHELIAL | 171 |
HEPATIC CALCIUM LEVEL AND | 183 |
DISCRIMINATIVE UPTAKE OF CADMIUM | 197 |
TISSUESPECIFIC METALLOTHIONEIN | 209 |
METALLOTHIONEIN SYNTHESIS IN RATS | 221 |
ASSESSMENT OF NUTRITIONAL STATUS BY | 323 |
POSSIBLE ROLE OF METALLOTHIONEINS IN | 339 |
INVOLVEMENT OF METALLOTHIONEIN IN THE | 347 |
THE POSSIBLE ROLE OF METALLOTHIONEIN | 359 |
POSSIBLE APPLICATION OF METALLOTHIONEIN | 375 |
CHRONIC CADMIUM EXPOSURE | 383 |
MEETING SYNOPSIS AND FUTURE DIRECTIONS | 393 |
INDEX | 403 |
عبارات ومصطلحات مألوفة
accumulation activity administration amino acid amounts analysis animals assay binding Biochem Biol biological blood bound Bremner cadmium caused cells changes Chem Cherian concentration containing copper cultured cysteine cytoplasm cytosol decrease detection determined domain dose effect elements et al exposure expression factor Figure fraction function Garvey gene given glutathione Hamer heavy hepatic human increased indicate induction injection involved isolated Japan Kägi kidney levels mammalian measured mechanism metal metal ions metallothionein method mg/kg mice mouse mRNA MT concentration MT gene MT-I normal observed plasma possible present pretreatment production promoter protein radical rat liver regulation renal reported residues response role sequence showed shown significant similar specific stress structure studies suggest Suzuki synthesis Table testes tissues toxicity Toxicol transcription treatment tumor University uptake urine various vitro Waalkes yeast zinc Zn-MT
مقاطع مشهورة
الصفحة 119 - Melton, DA, Krieg, PA, Rebagliati, MR, Maniatis, T., Zinn, K., and Green, MR (1984) Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter. Nucleic Acids Res. 12, 7035-7056.
الصفحة 360 - Lipid Research Clinics Program. The Lipid Research Clinics Coronary Primary Prevention Trial Results, II: the relationship of reduction in incidence of coronary heart disease to cholesterol lowering.
الصفحة 156 - BRADFORD, MM 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.
الصفحة 186 - Auron, PE, Webb, AC, Rosenwasser, LJ, Mucci, SF, Rich, A., Wolff, SM, and Dinarello, CA, Nucleotide sequence of human monocyte interleukin- 1 precursor cDNA.
الصفحة 117 - De Wet, JR, Wood, KV, DeLuca, M., Helinski, DR, and Subramani, S. (1987) Firefly luciferase gene: Structure and expression in mammalian cells.
الصفحة 337 - Protein content was determined according to the method of Lowry et al. (1951) using bovine serum albumin as a standard.
الصفحة 48 - Westhof, E., Altschuh, D., Moras, D., Bloomer, AC, Mondragon, A., Klug, A., and Van Regenmortel, MHV (1984) Correlation between segmental mobility and the location of antigenic determinants in proteins.
الصفحة 187 - Mitsuya, H., Looney, DJ, Kuno, S., Ueno, R., Wong-Staal, F. and Broder, S. (1988) Dextran sulfate suppression of viruses in the HIV family: inhibition of virion binding to CD4+ cells. Science 240, 646-649.
الصفحة 325 - Effect of zinc supplementation on the dietary intake, rate of weight gain and energy cost of tissue deposition in children recovering from severe malnutrition. Am J Clin Nutr 1981; 34: 900-908.
معلومات المراجع
| العنوان | Metallothionein in Biology and Medicine |
| المؤلف | Curtis D. Klaassen |
| الإصدار | مزود بصور توضيحية |
| الناشر | CRC Press, 1991 |
| رقم ISBN (الرقم الدولي المعياري للكتاب) | 0849388325, 9780849388323 |
| عدد الصفحات | 432 من الصفحات |
| تصدير الاقتباس | BiBTeX EndNote RefMan |