Chemistry and Biology of Pteridines and Folates: Proceedings of the 12th International Symposium on Pteridines and Folates, National Institutes of Health, Bethesda, Maryland, June 17–22, 2001Sheldon Milstien, Gregory Kapatos, Robert A. Levine, Barry Shane Springer Science & Business Media, 06/12/2012 - 677 من الصفحات Pteridine and folate research has long been recognized as important for many biological processes, such as amino acid metabolism, nucleic acid synthesis, neurotransmitter synthesis, cancer, cardiovascular function, and growth and development of essentially all living organisms. Defects in synthesis, metabolism and/or nutritional availability of these compounds have been implicated as major causes of common disease processes, e.g. cancer, inflammatory disorders, cardiovascular disorders, neurological diseases, autoimmune processes, and birth defects. Since pteridine and folate biology uses concepts and experimental techniques drawn from all of these disciplines, the breadth of this volume is its great strength, bringing together researchers from a wide variety of fields including biochemistry, chemistry, physics, biophysics, genetics, microbiology, cell and molecular biology, virology, immunology, cancer, neurobiology and medicine. This volume should be a valuable and unique reference work for scientists with interests in these areas as well as those seeking up to date information. |
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المحتوى
| 9 | |
| 24 | |
| 43 | |
Structure Function | 59 |
Conditions Associated with Dopamine Neuronal Damage | 60 |
Structure and Regulation of Phenylalanine Hydroxylase | 78 |
Role of Pheł13Trp326 in Determining Substrate Specificity | 96 |
The NTerminus of Human Tyrosine Hydroxylase is Responsible for | 114 |
Molecular Basis of DOPAResponsive Dystonia | 285 |
Human Nigrostriatal Dopamine Neurons Express Low Levels of | 290 |
The Fate of Intravenously Administered Tetrahydrobiopterin and | 305 |
CatecholOMethyltransferase Inhibition in the Treatment | 318 |
Clinical Utility of Pteridine Measurement in Cerebrospinal Fluid | 335 |
Tetrahydrobiopterin Deficiency in Diabetic Rats | 349 |
The Effect of Tetrahydrobiopterin BHA on Diabetic Nephropathy | 354 |
Role of Neopterin in Immune Monitoring in Transplant Medicine | 370 |
Role | 127 |
Mechanism and Regulation of Pteridine Biosynthesis | 145 |
Sexually Dimorphic GTP Cyclohydrolase I Gene Expression | 162 |
Determination of Residues Of Sepiapterin Reductase Phosphorylated | 181 |
The Interaction of GTP Cyclohydrolase I and GTP Cyclohydrolase | 186 |
Cells Take up BHA Oxidize it and the Oxidized Biopterin | 205 |
Pteridine and Nitric Oxide Biosynthesis in Physarum Polycephalum | 223 |
BH and NOS are Involved in Light Controlled Development | 240 |
Determination of Tetrahydropterins as Native Pteridines in | 247 |
Tetrahydrobiopterin and Endothelial Function | 258 |
The Redox Status of Bound Pterin Cofactor Determines Whether eNOS | 271 |
Clinical Aspects of Pteridines | 277 |
Neopterin and Biopterin Levels in Pregnancy | 387 |
The Role of Tetrahydrobiopterin BHA in Trophic Factor Withdrawal | 405 |
Solid and Solution Phase Strategies for the Synthesis of Potential | 421 |
Synthesis of N42Amino6Methyl34Dihydro4Oxo7hPyrrolo23 | 439 |
Molecular Mechanisms of Resistance to Antimalarial Antifolate Drug | 457 |
Induction of Resistance to the MultiTargeted antifolate MTA Ly231514 | 473 |
Effects of Cellular Glycine on Cell Proliferation | 490 |
Control Of Folate Production in Lactic Acid Bacteria by Using Metabolic | 623 |
Folate Transport Abnormalities and Congenital Defects | 636 |
Cell Biology and Regulation of the Intestinal Folate Absorption Process | 654 |
INDEX | 673 |
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عبارات ومصطلحات مألوفة
activity AdoMet amino acid analogue analysis antifolates apoptosis ascorbic assay binding Biochem Biochemistry Biol Chem biopterin biosynthesis brain Cancer catalytic cDNA clinical clones cobalamin cofactor coli compounds concentrations decreased deficiency detected determined DHFR DHPR dihydrofolate dihydrofolate reductase dimer disease domain dopamine effect enzyme expression Figure folate function gene glycine GTP cyclohydrolase GTPCH homocysteine HPLC human hydroxylation increased incubated induced inhibition inhibitor interaction intracellular kinetic L-dopa L-Phe levels liver mechanism membrane metabolism methionine synthase methyl methyltransferase molecular mRNA mutations neopterin neurons nitric oxide synthase oxidative stress pathway patients PC12 cells phenylalanine hydroxylase phosphorylation plasma production pteridine pterin reaction recombinant reduced regulation residues role sepiapterin reductase sequence serum shown spectra structure studies substrate sulfur synthesis Table tetrahydrobiopterin thymidylate synthase tissues transcription tryptophan tyrosine hydroxylase University vitamin vitro vivo wild type wild-type
