Chemistry and Biology of Pteridines and Folates: Proceedings of the 12th International Symposium on Pteridines and Folates, National Institutes of Health, Bethesda, Maryland, June 17–22, 2001

الغلاف الأمامي
Sheldon Milstien, Gregory Kapatos, Robert A. Levine, Barry Shane
Springer Science & Business Media, 06‏/12‏/2012 - 677 من الصفحات
Pteridine and folate research has long been recognized as important for many biological processes, such as amino acid metabolism, nucleic acid synthesis, neurotransmitter synthesis, cancer, cardiovascular function, and growth and development of essentially all living organisms. Defects in synthesis, metabolism and/or nutritional availability of these compounds have been implicated as major causes of common disease processes, e.g. cancer, inflammatory disorders, cardiovascular disorders, neurological diseases, autoimmune processes, and birth defects.
Since pteridine and folate biology uses concepts and experimental techniques drawn from all of these disciplines, the breadth of this volume is its great strength, bringing together researchers from a wide variety of fields including biochemistry, chemistry, physics, biophysics, genetics, microbiology, cell and molecular biology, virology, immunology, cancer, neurobiology and medicine. This volume should be a valuable and unique reference work for scientists with interests in these areas as well as those seeking up to date information.
 

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المحتوى

Structure Elucidations of Dimeric Pteridines
9
Solution and Solid Phase Synthesis of Pteridines Purines and Related
24
New Pyranopterin Chemistry Related to Molybdenum and Tungsten
43
Structure Function
59
Conditions Associated with Dopamine Neuronal Damage
60
Structure and Regulation of Phenylalanine Hydroxylase
78
Role of Pheł13Trp326 in Determining Substrate Specificity
96
The NTerminus of Human Tyrosine Hydroxylase is Responsible for
114
Molecular Basis of DOPAResponsive Dystonia
285
Human Nigrostriatal Dopamine Neurons Express Low Levels of
290
The Fate of Intravenously Administered Tetrahydrobiopterin and
305
CatecholOMethyltransferase Inhibition in the Treatment
318
Clinical Utility of Pteridine Measurement in Cerebrospinal Fluid
335
Tetrahydrobiopterin Deficiency in Diabetic Rats
349
The Effect of Tetrahydrobiopterin BHA on Diabetic Nephropathy
354
Role of Neopterin in Immune Monitoring in Transplant Medicine
370

Role
127
Mechanism and Regulation of Pteridine Biosynthesis
145
Sexually Dimorphic GTP Cyclohydrolase I Gene Expression
162
Determination of Residues Of Sepiapterin Reductase Phosphorylated
181
The Interaction of GTP Cyclohydrolase I and GTP Cyclohydrolase
186
Cells Take up BHA Oxidize it and the Oxidized Biopterin
205
Pteridine and Nitric Oxide Biosynthesis in Physarum Polycephalum
223
BH and NOS are Involved in Light Controlled Development
240
Determination of Tetrahydropterins as Native Pteridines in
247
Tetrahydrobiopterin and Endothelial Function
258
The Redox Status of Bound Pterin Cofactor Determines Whether eNOS
271
Clinical Aspects of Pteridines
277
Neopterin and Biopterin Levels in Pregnancy
387
The Role of Tetrahydrobiopterin BHA in Trophic Factor Withdrawal
405
Solid and Solution Phase Strategies for the Synthesis of Potential
421
Synthesis of N42Amino6Methyl34Dihydro4Oxo7hPyrrolo23
439
Molecular Mechanisms of Resistance to Antimalarial Antifolate Drug
457
Induction of Resistance to the MultiTargeted antifolate MTA Ly231514
473
Effects of Cellular Glycine on Cell Proliferation
490
Control Of Folate Production in Lactic Acid Bacteria by Using Metabolic
623
Folate Transport Abnormalities and Congenital Defects
636
Cell Biology and Regulation of the Intestinal Folate Absorption Process
654
INDEX
673
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