Programmed Cell DeathAlthough general morphological features have been used to consistently identify the changes in cell ultrastructure occurring during apoptosis, as distinct from necrosis, important advances have been achieved more recently in the investigation of the cellular and molecular aspects of this process. This book brings together the latest international research on the complex subject of programmed cell death, and covers such areas as the biochemical mechanisms, introduction of DNA fragmentation, enetic regulation, and the importance of apoptosis in the immune system, particularly during T-cell development, and in cancer. The comparison of a number of common signal transduction pathways with those involved in cell growth highlights an important relationship between apoptosis and the control of cell proliferation. |
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المحتوى
| 1 | |
| 19 | |
| 31 | |
| 45 | |
| 59 | |
| 73 | |
Induction of Apoptosis by the Immunomodulating | 87 |
GlucocorticoidInduced Programmed Cell Death | 99 |
The Role of Tumour Suppressor Genes in Apoptosis | 187 |
Altered Gene Expression During Apoptosis | 203 |
The Role of Apoptosis in the Regulation of | 219 |
| 229 | |
Apoptosis in the Target Organ of | 235 |
Peptide EpitopeInduced Apoptosis of Human | 245 |
Apoptosis in Irradiated Murine Tumours and Human | 259 |
AntiCancer Drugs and Apoptosis | 269 |
Evidence for the Role of an EndoExonuclease in | 111 |
Critical Changes in Apoptosis in Thymocytes | 123 |
Regulation of Programmed Cell Death | 145 |
Macromolecular Synthesis cmyc and Apoptosis | 153 |
The bcl2 Oncogene Regulates Lymphocyte | 167 |
Bcl2 Expression in the Prostate and its Association | 179 |
Apoptosis Resulting from AntiCancer Agent Activity | 279 |
HyperthermiaInduced Apoptosis | 297 |
Tubulin in Apoptotic Cells | 315 |
Index | 325 |
عبارات ومصطلحات مألوفة
acid activity addition agents antibody antigen apoptotic cells appears associated binding biochemical Biology c-myc Ca2+ calcium Cancer cause cell cycle cell lines cellular changes chromatin cleavage clones Cohen concentrations cultures cytoplasm cytotoxic damage dependent determined DNA fragmentation drug effect endonuclease et al evidence Experimental experiments expression factor Figure function gene glucocorticoid glucocorticoid-induced growth Harmon heat human immature important increase indicated induce apoptosis inhibition inhibitor involved isolated Journal Journal of Immunology Kerr killing kinase known leads levels lymphocytes mechanism mediated mice molecular morphological mRNA Nature necrosis normal nuclear nuclei observed occurs pathway possible presence prevent produced programmed cell death proliferation protein protein synthesis radiation receptor regulation Research response role Science selection sensitive showed shown signal similar specific stimulation structures studies suggested T-cell thymocytes tissues treated treatment tubulin tumour undergo vitro Wyllie zinc
مقاطع مشهورة
الصفحة 323 - Kerr, JFR, Wyllie, AH, and Currie, AR (1972) Apoptosis: a basic biological phenomenon with wide ranging implications in tissue kinetics.
الصفحة 15 - Yonish-Rouach, E., Resnitzky, D., Lotem, J., Sachs, L., Kimchi, A., and Oren, M. (1991) Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6. Nature. 352, 345-347.
الصفحة 241 - This work was supported by the National Health and Medical Research Council of Australia, the National Heart Foundation of Australia, the National SIDS Council of Australia, and the Flinders Medical Centre Research Foundation.
الصفحة 10 - Evan, GI, Wyllie, AH, Gilbert, CS, Littlewood, TD, Land, H., Brooks, M., Waters, CM, Penn, LZ, and Hancock, DC Induction of apoptosis in fibroblasts by c-Myc protein.
الصفحة 29 - Nishizuka, Y. (1984) The role of protein kinase C in cell surface signal transduction and tumour promotion.
الصفحة 14 - Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line. Proc. Natl. Acad. Sci USA 89, 4495-4499.
الصفحة 243 - Schwartz, RH (1989). Clonal expansion versus functional clonal inactivation: A costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy. Annu. Rev. Immunol 7, 445-480.
الصفحة 294 - Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: A cautionary note. Cancer Res. 49, 5870-5878.
الصفحة 96 - SJ (1991) bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell 67, 879-888.
الصفحة 11 - BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death. Proc. Natl. Acad. Sci. USA 88, 6961-6965 (1991).
معلومات المراجع
| العنوان | Programmed Cell Death |
| المؤلفون | Martin Lavin, Diane Watters |
| الناشر | CRC Press, 1993 |
| رقم ISBN (الرقم الدولي المعياري للكتاب) | 371865461X, 9783718654611 |
| عدد الصفحات | 331 من الصفحات |
| تصدير الاقتباس | BiBTeX EndNote RefMan |