Developmental ToxicologyThe Second Edition of this highly regarded work provides a state-of-the-art review of developmental toxicology from basic science, clinical, epidemiological, and regulatory perspectives. This new edition highlights the latest approaches to understanding the mechanisms of developmental toxicity, testing pharmaceutical and environmental agents, and interpreting developmental toxicity data.; The contributors demonstrate how new information on molecular embryology and cell biology is being applied to problems in developmental toxicology. Chapters describe the effects of toxic exposure on the functional development of various organs, examine the relationship between maternal and developmental toxicity, and discuss current techniques for studying chemical disposition, metabolism, and placental transfer. Close attention is given to the use of mathematical and statistical techniques in data interpretation, as well as to the regulatory aspects of testing and risk assessment. Other chapters focus on pre- and post conceptional clinical care and on genetic factors in clinical developmental toxicology. |
ما يقوله الناس - كتابة مراجعة
لم نعثر على أي مراجعات في الأماكن المعتادة.
المحتوى
| 15 | |
| 53 | |
| 65 | |
| 85 | |
Developmental Immunotoxicology | 93 |
Functional Toxicity in the Developing Heart Lung | 119 |
Relationships Between Maternal and Developmental | 189 |
PharmacokineticPharmacodynamic Approaches | 215 |
Preconception and Postconception | 307 |
Genetic Factors in Clinical Developmental Toxicology | 333 |
Statistical Analysis of Developmental Toxicity Data | 349 |
DoseResponse Modeling | 363 |
Testing of Pharmaceutical Agents for Reproductive | 379 |
Testing of Environmental Agents for Developmental | 403 |
Risk Assessment for Developmental Toxicity | 429 |
Subject Index | 455 |
طبعات أخرى - عرض جميع المقتطفات
عبارات ومصطلحات مألوفة
abnormal acid activity addition adult adverse agents alterations animals appear Appl approach assessment associated birth blood body brain cadmium cardiac cause cells changes chemical chick concentration decreased defects described determine developmental toxicity disease dose drug early effects embryo Environ environmental evaluation examined example experimental exposed exposure expression factors fetal fetus function gene gestation growth Health heart hormone human immune important increased indicate induced injection kidney lead levels lung malformations maternal maturation measured mechanisms mg/kg mice mouse neonatal normal observed occurs offspring organ pattern period Pharmacol physiological placenta points possible postnatal potential pregnancy prenatal Press produced protein pulmonary rabbit receptor reduced renal reported reproductive response risk secretion similar specific stage studies Table teratogenic Teratology tion tissue Toxicol Toxicology treatment weight women York
مقاطع مشهورة
الصفحة 150 - US Environmental Protection Agency, and approved for publication. Approval does not signify that the contents necessarily reflect the views and policies of the US Environmental Protection Agency; nor does mention of trade names or commercial products constitute endorsement or recommendation for use.
الصفحة 429 - The views expressed in this chapter are those of the authors and do not necessarily reflect the views or policies of the US Environmental Protection Agency.
الصفحة 279 - The P450 superfamily: Update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature.
الصفحة ix - National Institute of Environmental Health Sciences PO Box 12233 Research Triangle Park NC 27709, USA associate managing editor: S.
الصفحة 269 - A biomarker of susceptibility is an indicator of an inherent or acquired limitation of an organism's ability to respond to the challenge of exposure to a specific xenobiotic substance.
الصفحة 84 - Toxicological Principles for the Safety Assessment of Direct Food Additives and Color Additives Used in Food.
الصفحة 87 - Somatomedin-C mediates growth hormone negative feedback by effects on both the hypothalamus and the pituitary. Science 1981; 212: 1279-1281.
الصفحة 11 - LO, Hansman C. Boyd E. Intrauterine growth in length and head circumference as estimated from live births at gestational ages from 26 to 42 weeks.
الصفحة 209 - Cousins RJ. 1985. Absorption, transport, and hepatic metabolism of copper and zinc: Special reference to metallothionein and ceruloplasmin.
معلومات المراجع
| العنوان | Developmental Toxicology Target Organ Toxicology Series |
| المُحرر | CaroleAKimmel |
| الإصدار | 2, تمت مراجعته |
| الناشر | CRC Press, 1994 |
| رقم ISBN (الرقم الدولي المعياري للكتاب) | 0781701376, 9780781701372 |
| عدد الصفحات | 479 من الصفحات |
| تصدير الاقتباس | BiBTeX EndNote RefMan |