Introduction to Drug MetabolismNelson Thornes, 2001 - 256 من الصفحات Looks at both biochemical and physiological angles. Examples maintain clinical relevance so practical importance of subject can be appreciated. |
المحتوى
PATHWAYS OF DRUG METABOLISM | 1 |
31 | 15 |
ENZYMOLOGY AND MOLECULAR MECHANISMS OF DRUG | 37 |
INDUCTION AND INHIBITION OF DRUG METABOLISM | 87 |
39 | 116 |
PHARMACOLOGICAL AND TOXICOLOGICAL ASPECTS | 171 |
THE CLINICAL RELEVANCE OF DRUG METABOLISM | 203 |
INDEX | 243 |
طبعات أخرى - عرض جميع المقتطفات
عبارات ومصطلحات مألوفة
2-Acetylaminofluorene acetylation amino acid aminopyrine animals antipyrine benzo[a]pyrene bilirubin binding Biochem biotransformation catalysed cell Chapter clearance clinical complex concentration COOH CYP2B CYP3A cysteine cytochrome P450 cytochrome P450-dependent debrisoquine decrease diazepam dose drug metabolism drug oxidation drug-metabolising capacity drug-metabolising enzymes drugs and xenobiotics effect endogenous compounds endoplasmic reticulum enzyme activity enzymes epoxide hydrolase ethanol example excretion factors forms of cytochrome function gene genetic glucuronidation glutathione glutathione conjugation haem haemoprotein hepatic hepatic cytochrome P450 hepatic drug metabolism hepatocytes hormone human liver hydrocarbons hydroxylation increase inducers induction of drug inhibition of drug inhibitors interaction involved isoniazid kidney levels ligands lipid liver mechanisms metab metabolising enzymes microsomal mixed-function oxidase molecular N-demethylase NADPH NADPH-cytochrome P450 reductase paracetamol pathways pharmacokinetic Pharmacol pharmacological phase 2 metabolism phenobarbitone plasma polymorphisms protein receptor reduced resulting role shown in Figure steroid studies substrate specificity sulfate sulfotransferase Table tissue toxicity toxicological transcription transferase UDP-glucuronosyltransferase vitamin Xenobiotica xenobiotics zoxazolamine